Steffie Beijnsberger (born on the 8th of January 1990) obtained her B.Sc. and M.Sc. degrees in Biomedical Sciences at the Radboud University of Nijmegen. During her bachelor she performed a short internship of four months at the Biomaterials department at the Radboud University, supervised by Wanxun Yang and Dr. Sanne Both. Here, she studied the influence of vitamin D and retinoic acid on mesenchymal stem cells with the purpose to improve the amount of cartilage formation and to shorten the culture time period of endochondral ossification.
In her master program she choose to go abroad for eight months and performed an internship at the Pediatrics department at the University of Washington, Seattle, USA. Assistant Professor Heather Mefford, MD, PhD and Post-Doctoral Fellow Gemma Carvill, PhD supervised her to investigate the role of several genes in the development of polymicrogyria (a brain disorder). Steffie screened 340 individuals with this disorder by mutation analyses using molecular inversion probes and next-generation sequencing. After eight months she presented her work on a poster at the American Society of Human Genetic Conference in Boston. To complete her Master degree, Steffie performed at six months internship at Synthon Biopharmaceuticals B.v. in Nijmegen, supervised by Ellen Mattaar and Dr. David Egging. During this internship she investigated the suitability of the Octet instrument for measuring ligand-ligand interactions. The goal was to replace current ELISA techniques with an assay on the Octet instrument to measure total antibody and/or toxin conjugated antibody content in Pharmaco-Kinetic samples.
Her interest in genetics and functional analyses brought her to join the group of assistant professor Blanche Schroen, PhD. She will face a challenge in for her a new area, cardiovascular research. She will focus on the role of microRNA’s (miRNAs) and long non-coding RNAs (lncRNAs) in the development of Heart Failure (HF). The goal is to unravel the role of novel lncRNAs in the heart, to define which molecular pathways are affected and investigate which role the immune system plays in this whole.