New CVON grant. Eearly-HFPEF

Het Maastrichtse hartfalen-onderzoeksteam onder leiding van prof. dr. Stephane Heymans heeft een miljoen euro subsidie van de Nederlandse Hartstichting verworven. Samen met onderzoekers van de Vrije Universiteit Amsterdam gaan ze de komende vijf jaar op zoek naar vroege voortekenen van een specifieke vorm van hartfalen die veel voorkomt bij vrouwen. "De samenwerking tussen de afdeling Cardiologie van het Maastricht Hart+Vaat Centrum en de universitaire onderzoekschool CARIM werpt wederom zijn vruchten af", aldus professor Heymans. We zijn een sterk team.

The Maastricht heart failure research team, led by Professor Stephane Heymans, was awarded a million-euro grant from the Nederlandse Hartstichting (Dutch Heart Foundation). 
Together with researchers at the Vrije Universiteit Amsterdam, they will spend the next five years researching the early indicators of a specific form of heart failure that is common among women. 'The collaboration between the Cardiology Department at Maastricht UMC+ and the CARIM research institute is once again paying off,' says Professor Heymans. 'We're a formidable team.' When the heart starts to lose its elasticity, the muscle has trouble relaxing, resulting in higher blood pressure in the heart and lungs. This can lead to shortness of breath and heart failure. This particular type of heart failure, known as HFPEF, is more common in women aged 65 and older and people with obesity, high blood pressure, diabetes and/or kidney failure. In many patients, this loss of elasticity has progressed for several years before symptoms occur. At the moment, the disease is untreatable and irreversible. Early detection is therefore important to prevent unnecessary suffering. Early warning signs This is exactly what UM researchers Anna Papageorgiou and Mathijs Blankesteijn plan to research under the supervision of Professor Heymans and Dr Vanessa van Empel. They hope to uncover the early warning signs, such as biomarkers, that could indicate a decline in heart health. Preclinical diastolic dysfunction (pDD) is a condition that causes HFPEF in thirty percent of patients. Identifying pDD is an important objective of the study. The multidisciplinary project group will study the predictive biomarkers and other patient characteristics that could help detect pDD at an early stage and contribute to the development of tailored treatment.

Awards for two young heart failure researchers

Two Maastricht researchers recently won prestigious awards at the world's biggest heart failure conference, Heart Failure 2016, organised by the European Society of Cardiology. Dr Ward Heggermont and Dr Mark Hazebroek, both researchers and practicing medical doctors, were two of the award recipients at the four-day conference in Florence, which was attended by well over six thousand participants. Dr Ward Heggermont won first place in the category 'Basic Research'. He found that a tiny functional RNA fragment, microRNA-146a, plays an important role in the energy metabolism of the failing heart. One of the characteristics of a failing heart is impaired energy metabolism. The micro-RNA fragment was found to suppress a citric acid enzyme (DLST), a discovery that requires further research but may prove useful in the development of targeted therapy for heart failure in the future. Dr Mark Hazebroek placed second in the European Society of Cardiology's Young Investigator Award. Hazebroek is involved in research on genetic mutations in patients with an enlarged heart, also known as dilated cardiomyopathy. He compared these patients with a group of patients in an earlier stage of the disease and found that genetic mutations could lead to arrhythmias and premature death in both groups. These findings have potential consequences for preventative treatment strategies, such as an implanted cardiac defibrillator (ICD). Both researchers work under the supervision of Professor Stephane Heymans at the CARIM research school in Maastricht.

Landmark paper on gene-environmental interactions in dilated cardiomyopathy patients

The group of Stephane Heymans has published out of their Maastricht Cardiomyopathy Registry a sample of 214 purely dilated cardiomyopathy patients. This study reveals that the interaction between gene mutations and the acquired/environmental factors (viruses/inflammation/toxic) are predicting outcome, where gene mutations or acquired triggers do not predict outcome. It has been published in JACC and commented by Prof. Fuster

Outstanding achievement award nomination

Stephane Heymans, Professor of Cardiomyopathies, has been nominated to receive an Outstanding Achievement Award by the European Society of Cardiology (ESC) Council for Basic Cardiovascular Science.These awards honour basic researchers with outstanding accomplishments in the early stage of their career.
Professor Heymans will receive his award at the ESC Congress in September 2015.

HFA Young investigator award for Mark Hazebroek

Mark Hazebroek has got the prestigious Young Investigator Award Clinical Research during the annual meeting of the "European Heart Failure Association van de ESC."  He presented his work on the “Prognostic relevance of gen-environmental interactions in dilated cardiomyopathy patients: applying the MOGES classification.”

Faces of science KNAW

You can now watch Marieke talk about her research, as part of the “ Faces of Science”  initiative of the KNAW en de jonge akademie.  https://www.kennislink.nl/facesofscience/wetenschappers/marieke-rienks

Bangalore Projects

Prof.dr. Stephane Heymans intitiated new clinical and research projects at different institutions in Bangalore, including the Mazumdar Shaw Cancer Centre and Narayana Hrudayalaya Multispecialty Hospital. His mains scientific collaboratos are Prof.dr. Paul Salins and Prof.dr. Arkasubhra Ghosh at the research department, with dr. Samarth Shetty as a possible first MD, PhD student.
The research projects include discovery of novel therapeutic targets in heart failure, ocular diseases and related co-morbidities.

Project homage FP7 cooperation by Blanche Schroen and Stephane Heymans accepted

Blanche Schroen and Stephane Heymans just got the excellent news that the European project proposal "Homage" (FP7 cooperation), coordinated by Faiez Zannad from Paris, has been accepted.  Their group has a major contribution in this project, called "Heart 'omics in AGEing" for the validation of -'omics-based biomarkers for diseases affecting the elderly". They will participate as both clinical and preclinical partner

VIDI 2013 for dr. Blanche Schroen

Youtube: https://www.youtube.com/v/yysqcnUTEbQ

Dr. Blanche Schroen (Cardiologie) ontvangt maximaal € 800.000 om een vernieuwende onderzoekslijn te ontwikkelen en een eigen onderzoeksgroep te bouwen. Zij ontvangt een Vidi uit de Vernieuwingsimpuls van de Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO), bestaande uit Veni, Vidi en Vici.

Immuuncellen in het hart ontmaskerd

Ondanks de aanwezigheid van immuuncellen in gezonde en zieke harten, is hun bijdrage aan het (dis)functioneren van de hartspier onderbelicht. De onderzoekers vonden dat recent-ontdekte niet-coderende genen zoals “mascRNA” immuuncelgedrag aansturen. Onderzocht wordt of mascRNA in immuuncellen bijdraagt aan hartfalen.